Plz Recalculate expt 2a If I will start with 0.05 g 1a (nitrophenyl pyrrole ). T
ID: 1008308 • Letter: P
Question
Plz Recalculate expt 2a If I will start with 0.05 g 1a (nitrophenyl pyrrole ). Thanks I am always rate 5.2.1. Preparation of 1-(4-nitrophenyl)-1H-pyrrole/indole (1a-1b) A well-stirred mixture of pyrrole/indole (0.128 mol) and K2CO3 (35.4 g, 0.257 mol) in DMF (150 mL) was heated at 100 °C for 30 min. Then, p-fluoronitrobenzene (21.6 g, 0.153 mol) was added and the mixture was stirred for another 5 h. Upon cooling to room temperature, the mixture was poured into water (300 mL) to stir for 30 min and filtered. The residue was washed with water, dried to Iro- give crude product and then treated with diethyl ether to afford ro1a 1a-1bExplanation / Answer
nitrophenyl pyrrole ( M.wt = 188.18 g/mol) 1a ( 0.05 g , 2.66*10-4 mol ( 0.27 mmol)).
FeCl3.6H2O (M.wt 270.3 g/mol) = 11.08 mg ( note 11.08 is in mg not in gram) 0.041 mmol.
Activated carbon ( M.wt 12 g/mol) = 0.97 mg , 0.081 mol
1,4-dioxane = 14.36 mL but as a solvent you can use 15 mL
Hydrazine hydrate (M.wt 50.06 g/mol) = 135.2 mg, 2.7 mmol
Reflux time should be same as 5 hr.
for quenching 15 mL water is sufficient.