Analyze the pedigree given here, answering the questions that follow. a. What is
ID: 101641 • Letter: A
Question
Analyze the pedigree given here, answering the questions that follow. a. What is the most likely mode of inheritance of this trait: autosomal or X-linked? Give and explain at least two reasons to support your answer, referring to specific examples in the pedigree. b. What is the most likely mode of inheritance of this trait: dominant or recessive? Give a reason to support your answer, referring to a specific example in the pedigree. c. Providing a legend for your symbols, give the genotypes of these six individuals I-2, II-2, II-4, III-2, III-6, IV-11.Explanation / Answer
a.Mode of inheritance is X linked. In X linked inheritance a mutation in a gene on the X chromosome causes the phenotype to be expressed in males (who are necessarily hemizygous for the gene mutation because they have one X and one Y chromosome) and in females who are homozygous for the gene mutation,
b.X-linked recessive inheritance is a mode of inheritance in which a mutation in a gene on the X chromosome causes the phenotype to be expressed in males (who are necessarily hemizygous for the gene mutation because they have one X and one Y chromosome) and in females who are homozygous for the gene mutation.
c I-2.Normal male-XY
II-2 Normal female -XX
II-4 Normal male- XY
III -2 Affected male XY
III-6 Normal male- XY
IV -11- Carrier female - XX