Predict the solubility of 300mg of each of the solute in each of the solvent, an
ID: 1035476 • Letter: P
Question
Predict the solubility of 300mg of each of the solute in each of the solvent, and give reasons. Indicate whether the solute dissolves in the solvent OR reacts with the solvent, what product(s) is/are formed, and what is the equations. *Please also explain why this solute dissolves in that solvent, or why this solute reacts with that solvent in detail. Thanks
Page 14 of 23 SOLUBILITY OF SELECTED SOLUTES IN DIFFERENT SOLVENTS Solvents Solute Structure Pharmaceutical | water | 5%w/v | 5% w/v | 025 M | 95% dichloromethane NaHCOs NaOH HC1-1 ethanol. use NaCl sodium chloride diverse uses COOH salicylic acid keratolytic agent OH antimalarial agent quinine (supplied as quinine sulfate) palmitic acid soap formation local anaesthetic analgesic and antipyretic paracetamol 2017 PHA1PFA_practical manual docs ? ENG chExplanation / Answer
NaCl
It is a salt made by Na+ and Cl- and is soluble in water. No chemical reaction takes place with water.
It does not react with basic (naHCO3, NaOH) or acidic (HCl) solution. However, these three solutions are made with water. So, NaCl dissolves in these three solutions.
With the virtue of having 5% water in 95% ethanol, NaCl dissolves in there too, but the solubility is much less as compared with its solubility in pure water.
NaCl is not soluble in organic solvents like dichloromethane. No chemical reaction.
Salicylic acid
It is partially soluble in water. Solubility increases at higher temperature. No chemical reaction.
Being an acid, it reacts with basic solutions (NaHCO3 and NaOH) and forms sodium salicylate, which is soluble in water. NaOH is a stronger base than NaHCO3. Therefore it eventually deprotonates the -OH group, too.
It should not react with HCl. However, being aqueous solution, salicylic acid may get partially dissolved in it.
With the virtue of containing the benzene ring, salicylic acid is soluble in dicholoromethane. No chemical reaction.
Salicylic acid is highly soluble in ethanol.
Quinine sulphate
As it contains multiple number of 6-membered aromatic ring and a cage structure, it is slightly soluble in water, 95% ethanol and dichloromethane at neutral pH.
At acidic pH (0.025 M HCl), -OH, pyridyl - N and the N adjacent to the bridgemay get protonated.
There should not be any reaction with weak base NaHCO3. However, strong base NaOH can deprotonate -OH.
Palmitic acid
It is not soluble in water and ethanol due to long alkyl chain.
It should be highly soluble in dichloromethane.
Being acid, it should react with NaHCO3 and NaOH to generate Sodium palmitate.
There should not be any reaction with HCl.