AT&T; 1:24 PM @ 56% EXTRA CREDIT.docx Solution Pka Pka2 Pka3 2.10 3.86 9.82 2.10

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AT&T; 1:24 PM @ 56% EXTRA CREDIT.docx Solution Pka Pka2 Pka3 2.10 3.86 9.82 2.10 4.07 9.47 2.32 976 NIA 2.18 9.04 12.48 5. Which solution contains an amino acid that would be most likely to stabilize an anionic substrate in an enzyme pocket at physiological pH? A) solution 1 b) solution 2 c) solution 3 d) solution 4 6. The antibiotic chloramphenicol is a competitive inhibitor of an enzyme involved in translation elongation. Using knowledge of Michaelis-Menten kinetics, what effect would the addition of chloramphenicol have on the kinetics of its target enzyme?a) Vmax decreases, Km increases b) V max decreases, Km remains unchanged c) Vmax remains unchanged, Km increases d) V max remains unchanged, Km decreases 7. Platelets carry 95% of blood serotonin. Serotonin functions as a hormone and neurotransmitter in many systems. Researchers believe that platelet serotonin may play a role in the observed positive effect of platelets upon hepatocyte proliferation. The chemical structure of serotonin is shown below: Where are the serotonin receptors most likely to be located in hepatocytes? A) in the nucleus b) in the cytosol c) embedded in the mitochondrial membrane d) embedded in the cell membrane 8. Based on the information given in question 7, the amino acid precursor of serotonin is best described as having which type of R-group? A) nonpolar, aliphatic b) Polar, uncharged c) aromatic d) Negatively charged Open With Print

Explanation / Answer

5 -d correct because at physiological pH this amino acid will stay as cationic species and stabilise the anionic enzyme.

6 -a

7 -c

8 -c

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