The biologically active turmeric isolate curcumin (1) is under development as an

Question

The biologically active turmeric isolate curcumin (1) is under development as an anti-cancer chemotherapeutic agent. Recent mechanism-of-action studies have identified one potential target, the nuclear exporter protein CRM 1. Curcumin inhibits nuclear trafficking by this protein, an activity that is speculated to underlie the promising anticancer and anti-inflammatory activity of 1. In fact, these studies suggest that curcumin forms a covalent linkage to one particular amino acid sidechain of CRM1as the basis for its inhibitory activity. Which amino acid is likely involved? Select one; a b c d

Explanation / Answer

answer is option b

explanation:

in th emolecule -1 one of the functional group is unsaturated ketone

alanine is a nuetral side chain so its side chain doent interact with this

Asperitic acid is acidic side chain carboxylic acid functional group cannot react with

hydroxy group of the serine cannot attack the conjugate carbon of the unsaturated ketone

cystine side chain only can react with this so opton b is correct answer

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