Phosphorylation of glucose requires 1 ATP. Can the reverse reaction be used for
ID: 1075636 • Letter: P
Question
Phosphorylation of glucose requires 1 ATP. Can the reverse reaction be used for substrate-level phosphorylation?
A. Yes, the breakdown of ATP in a metabolic reaction is always balanced with the synthesis of ATP in the reverse reaction.
B. No, phosphate hydrolysis of glucose-6-phosphate is not spontaneous enough to couple to ATP synthesis.
C. Yes, any reaction that involves ATP in either the forward or reverse direction is considered substrate-level phosphorylation.
D. No, ATP is primarily produced through oxidative phosphorylation, and there is an insufficient amount of ADP available for substrate-level phosphorylation to occur.
Explanation / Answer
D. No, ATP is primarily produced through oxidative phosphorylation, and there is an insufficient amount of ADP available for substrate-level phosphorylation to occur because
Oxidative phosphorylation is a process by which most ATPs (~=34-36) are produced in cellular respiration with in the mitochondria.
A variety species enzyme in the membrane called ATP synthase will take protons and transport (move)them into the matrix. In doing so, energy is released and used to phosphorylate ADP into ATP.So energy is consumed and insufficient energy is available for substrate level phosphorylation.