DiW the structures of the predominant ionization state of the amino acid at pH 1

Question

DiW the structures of the predominant ionization state of the amino acid at pH 1, 4, 8, and 12. Determine its net charge. For each pH, ill the amino acid migrate toward anode (+) or anode when placed in an electric field. c.) Calculate the isoelectronic point (pl) of each amino acids. 2.) Kyotorphin, first isolated in Kyoto, Japan from bovine brain, is a neuroactive dipeptide which plays a role in pain regulation in the brain. This dipeptide (T-R) has an analgesic effect but does not interact with opioid receptors. Instead, it acts by releasing met- enkephalin and stabilizing its degradation. a. Write the equilibrium ionizations for the peptide and assign the proper pK, for each ionization. What is the structure of the dipeptide when a solution of this peptide was reacted with HCI until the solution reach a pH-9.5? b. c. At what pH is the dipeptide most insoluble in water (H0)?

Explanation / Answer

part c

kyotorphin is soluble in distilled water only that too upto 2mg/ml otherwise for its solubility acetonitrile can be used.

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