Researchers studying the amino acid sequence in the calcium-binding protein cent

Question

Researchers studying the amino acid sequence in the calcium-binding protein centrin in humans found the following protein sequence: lys-ser-pro-ser-leu-asn-ala

As a result of a deletion of a single nucleotide and subsequent insertion of another nucleotide this amino acid sequence was found to change to: lys-val-his-his-leu-met-ala

Using a codon table (http://passel.unl.edu/Image/siteImages/Table1gif.gif), determine the nucleotide sequence that produces the original amino acid sequence and determine the subsequent changes to give the new peptide sequence.

Explanation / Answer

The original peptide sequence is: Lys-Ser-Pro-Ser-Leu-Asn-Ala --------------------------------------------- The original sequence of codons is: AAA-AGU-CCA-UCA-CUU-AAU-GCU -------------------------------------------------- The sequence with the deleted nucleotide highlighted is: AAA-AGU-CCA-UCA-CUU-AAU-GCU -------------------------------------------------- The sequence after deletion: AAA-GUC-CAU-CAC-UUA-AUG-CU --------------------------------------------------- The sequence with inserted nucleotide: AAA-GUC-CAU-CAC-UUA-AUG-GCU ------------------------------------------------------ The peptide sequence after the deletion and insertion is: Lys-Val-His-His-Leu-Met-Ala

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