Imagine a human with a macrophage mutation. These mutated macrophages do not pha

Question

Imagine a human with a macrophage mutation. These mutated macrophages do not phagocytose bacteria as they are supposed to. Instead, they tend to phagocytose and digest histamines.

How will these mutant humans be different from normal humans? In particular, answer these three questions in a sentence or less each:
-Will these mutants be more or less susceptible to bacterial infections?
-Will these mutants be able to destroy any of the bacteria at all?
-How will signaling be different in these mutants?
-What parts of the innate immune response will not be present in these mutants?

Explanation / Answer

These mutant humans will differ from normal humans in their immunity. ------------------------- These mutants will be more susceptible to bacterial infections. ---------------------------- These mutants will be able to destroy bacteria as the other cells of immune system like neutrophils, dendritic cells, basophils and eosinophils. ---------------------------- Signaling will be different in the macrophage pathway only. The receptors for bacteria will be changed or mutated to receptors for histamines. ---------------------------- The part of the innate immune response which will be affected due to lack of histamines would be allergy or the response of the innate immune system to an allergen.

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