In the context of a randomized controlled trial, sometimes intervention and/or c
ID: 127908 • Letter: I
Question
In the context of a randomized controlled trial, sometimes intervention and/or control subjects do not follow through with the treatments they are prescribed. In this situation, we should analyze our data as follows:
A)
We should compare those who successfully completed and complied with the treatment compared to those that truly did not, regardless of which group they were originally randomized to.
B)
We should compare those originally assigned to the intervention group to those originally assigned to the control group, even if subjects did not comply with the treatments they were prescribed.
C)
When we analyze our data, we should disregard all the subjects who did not comply with their prescribed treatments, and only analyze data from those that were compliant.
D)
We should not analyze our data because when there is noncompliance, the data is too flawed for analysis.
E)
None of the above
A)
We should compare those who successfully completed and complied with the treatment compared to those that truly did not, regardless of which group they were originally randomized to.
B)
We should compare those originally assigned to the intervention group to those originally assigned to the control group, even if subjects did not comply with the treatments they were prescribed.
C)
When we analyze our data, we should disregard all the subjects who did not comply with their prescribed treatments, and only analyze data from those that were compliant.
D)
We should not analyze our data because when there is noncompliance, the data is too flawed for analysis.
E)
None of the above
Explanation / Answer
Answer C
After the completion of trial while we are analysing the data we should exclude the subjects who are not complined to it. We should mentioned that withdrawn from the study due to non compliance
So when we analyze the data we should exclude all the subjects who are not complined to protocol/prescribed treatments and analyse the data from those who are compliant.