8. The costimulatory signal needed for complete T cell activation occurs between

Question

8. The costimulatory signal needed for complete T cell activation occurs between on the T cell and on 9. PIP, is split by a to yield DAG and IP What are the roles of the following molecules in the signal transduction pathway leading from the T-cell receptor: (1) the CD3 complex ( ii) protein tyrosine kinase Lck; (ii) CD45 :(iv) ZAP- 70 (v) the chain (vi) IP3; and (vii) calcineurin? 10. Describe two ways in which T-cell tolerance is achieved 11. List and describe 3 ways the mother's body tolerate the fetus

Explanation / Answer

Costimulatory signal needed for complete Tell activationoccurs between T cell receptor (TCR) on theT cell and peptide-MHC molecules on the membrane of antigen presenting cells (APC)

Co-stimulation is required in addition to the antigen-specific signal from their antigen receptors

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