Please help me with these questions with show workings. Please this a pharmacolo
ID: 139592 • Letter: P
Question
Please help me with these questions with show workings. Please this a pharmacology question I select biology for me to able to post it but is pharmacology question Thank you.
1. Digoxin is a positive inotropic drug used in the treatment of heart failure. It is routinely administered orally, with the standard formulation being 0.375 mg tablets. A. Calculate a typical loading dose of digoxin. B. Calculate the maintenance dose, assuming that the patient will administer the drug once daily C. How many tablets should be administered each day? 2. Also an important drug for cardiovascular applications, metoprolol is formulated in tablets containing varied doses; 25 mg, 50 mg, 100 mg. Assuming that you would like the patient to be taking the drug twice a day (8:00 a.m. and 8:00 p.m.), answer the following: A. Calculate the maintenance dose. B. How many tablets should be administered at each dosing? C. Assuming no loading dose is given, approximately how long will it take to reach the steady-state target plasma concentration? 3. Cyclosporine, a potent immunosuppressor, is commonly administered to organ transplant recipients. Drug formulations include a solution that can be administered orally The solution is commonly prepared at a concentration of 100 mg/ml. A. Calculate the loading dose necessary to rapidly achieve steady-state target plasma concentrations B. How many ml of the solution should be consumed in this loading dose? C. Calculate the maintenance dose (in mg) assuming a once daily administration. D. How many ml of the solution must be consumed? 4. We all know acetaminophen, or Tylenol, comes in many different formulations and is a potent analgesic. Assuming a patient has a bottle of 325 mg capsules already on hand and you recommend the administration of the drug every 4-6 hours to lessen the pain, answer the following: A. If the patient is in serious pain, a loading dose might be recommended. How many capsules should be administered in this loading dose? B. How many capsules should be consumed at the noted schedule in order to achieve steady state plasma concentrations? Is this logical? Recommendations?Explanation / Answer
1.
Digoxin 0.375 mg tablet is an higher dose of digoxin tablet,a loading dose to initiate digoxin therapy in most of the patients with eart failure
A.The loading dose of the digoxin is 0.125 -0.25 mg orally stat for 5-7 days stat according to the patient condition
B.The maintanance dose is 0.375 mg orally daily
C.The patient has to take 2 tablets of 0.1875mg daily
2.
A. 100mg orally twice a day as maintanance dose in late treatment
B. Each dosing of 100mg of 1 tablet should be administered
C.Peak-blood levels of metoprolol are reached between 2 and 4 hour after ingestion
3.
A.
The loading dose ie,
B.The maintanance dose is
1-2wk post-transplant:15mg/kg/day PO divided BID
Reduce 5% per week until:5-10mg/kg/day PO divided BID
C.The medicine will be available 100mg/ml,If patient is having 50kg the patient has to take 7.5 ml of solution
4.
A.The patient has to take the loading dose of 325mg PO q4hr according to the level of pain
B.The dose of the Tylenol should not exceed 3250mg/day ie maximum of 10 tablets under the supervision of health professional