Fluocinolone acetonide is a topical corticosteroid drug with anti-inflammatory p
ID: 1409349 • Letter: F
Question
Fluocinolone acetonide is a topical corticosteroid drug with anti-inflammatory properties. The release
of fluocinolone acetonide from a patch with a cross-sectional area of 11 .5 cm2 and a membrane
thickness of 72 m was investigated. The lag time of diffusion was calculated to be 8.45 min. The
concentration of fluocinolone acetonide inside the patch is 4.5 x 10-5 g cm-3.
(a) Calculate the permeability coefficient (in cm s-1) of fluocinolone acetonide from this patch (K =
2.43).
(b) Calculate the total amount of fluocinolone acetonide (in g) released from the patch in 24 hrs
Explanation / Answer
a) the permeability coefficient = 1232.01/(8.45 * 60)
= 2.43 cm/sec
b) total amount of fluocinolone acetonide = 2.43 * 10-2 * 24 * 3600 * 72 * 10-6 * 4.5 x 10-5/11.5
= 0.5915 g