In graduate school, you study genes involved in cancer. In the strain of mice th
ID: 145686 • Letter: I
Question
In graduate school, you study genes involved in cancer. In the strain of mice that you study, each mouse usually gets one tumor within the first year. You isolate two mutations: a mutation in gene T that leads to formation of no tumors, and a mutation in gene G that leads to multiple tumors. You generate double-mutants and find that they have no tumors. If the genes act in a signaling pathway, which gene is likely epistatic, and which gene likely functions downstream? Answer in complete sentences.
Explanation / Answer
Here the mutation of gene G is epistatic. And mutation of gene T is downstream. The gene which fuctioning as epistatic. Epistasis is the phenomenon where the effect of one gene will depend on either in the presence one or more gene.. The depentive shows downstream functioning. Here Gene G contains doble mutants and mutation of gene G lead to tumor. But in mice Gene G induces tumor with the presence gene T(Downstream functioning)