In the figure above, the role of a large amount of ingested salt in amino acid a
ID: 148039 • Letter: I
Question
In the figure above, the role of a large amount of ingested salt in amino acid and bile acid absorption in DKO mice was investigated. Put this together with previous data on glucose. What can be concluded from the data?
What is another conclusion that can be made?
From your General Cell Biology knowledge, what process was investigated?
Na+ is required for optimum transport of a variety of nutrients A Absorption of amino acids 0.8 2 0.6 E0.4 0.8 Essential amino acids 0.6 ThrProAla Tyr AsnGluAspGin 0.4Gly CysArgSer Bile acid absorption with addition of Na 0.2 50 0.2 0.2 DKO 940 DKO+Li 0 15 30 45 60 0 15 30 45 60 Time after AA administration (min) S 30 B Amino acid absorption with addition of Nat or Li Essential amino acids 0.8 2 0.6 0.4 E 0.2 0.8 0.6 0.4 0.2 O 20 ThrProAla-Tyr Asn GluAspGIn Gly --"Cys --Arg -Ser DKO +200 mM LiCI 0.2 DKO +200 mM NaC 0.2 0.4 0 15 30 45 60 0 15 30 45 60 Time after AA administration (min)Explanation / Answer
The conclusions from the above data are-
Na+ is required for optimum transport of a variety of nutrients. Because from the graph we can observe, only in the presence of Na+ ions amino acids and bile acids absorptions take place efficiently, from serum to the tissues, with respect to time.
Another conclusion that can be made-
Transport of a variety of nutrients in the DKO mouse was reduced because of only kinetic considerations. Because kinetic considerations include time period, rate of the reaction etc. Here from the graph, it can be seen that with increasing time, the rate of amino acid absorption is also changing.
The process which was investigated is-
Facilitated diffusion, in which solutes pass through membranes across concentration gradient. charged or polar solutes like salt, amino acids can be transported with the help of certain carrier proteins.