3. The DNA sequence below contains the entire coding region for a gene. Below th

Question

3. The DNA sequence below contains the entire coding region for a gene. Below that is the amino acid sequence of the protein coded for by the gene. A cell suffers a mutation that results in an altered protein being produced (shown below). Describe the location and type of mutation that has occurred. DNA sequence: 5'AACAGCATAAACACAAAATCCATCAAAAATGTCGATGAAATATCTGATGTTGTTGTTCG 3 'TTGTCGTATTTGTGTTTTAGGTAGTTTTTACAGCTACTTTATAGACTACAACAACAAGC 5, 5 CTGCTATGATAATTAGATCATTCGCCAATAGTGGTAACGCTATCGAAACGACATTGTCA3 3' GACGATACTATTAATCTAGTAAGCGGTTATCACCATTGCGATAGCTTTGCTGTAACAGT 5 S' AGAATTACAAACACTACAACAGATATTCCAGCTATCTGATTATGCGGTCCAGAGGGAAA 3 3 TCTTAATGTTTGTGATGTTGTCTATAAGGTCGATAGACTAATACGCCAGGTCTCCCTTT 5 Original Protein Sequence: MLLFAAMIIRSFANSGNAIETTLSRITNTTTDIPAI Mutated Protein Sequence: MLLFAAMIIRSFANSGNANRNDIVKNYKHYNRYSSYLIMRSRGK

Explanation / Answer

The answer to the question is that the mutation is occuring at the 19th position of the original protein sequence.i.e.,amino acid I is replaced by amino acid N.

The possible mutation can be frame-shift mutation and missense mutation.Since at 19th position of the protein sequence,there may be a change in one DNA base pair that results in the substitution of one amino acid for another amino acid for the protein made by the gene.

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