Assigned as Homework O TRP operon A bacterial strain has a mutation in the TRP r

Question

Assigned as Homework O TRP operon A bacterial strain has a mutation in the TRP repressor which prevents the protein from ever binding tryptophan. How would you predict this mutation would affect expression of the TRP operon? O AExpression of TRP operon in the presence of tryptophan, but repression in the absence of tryptopharn O B Repression of Trp operon in the absence of tryptophan, but expression in the presence of tryptophan C Repression of the TRP operon in the presence or absence of tryptophan O D Expression of the TRP operon in the presence or absence of tryptophan O E t is not possible to determine

Explanation / Answer

The correct option is "d". Expression of TRP operon in the absence or presence of tryptophan.

Reason: In the usual scenario, high concentration of Trp will always keep the repressor in active state (binding of Trp to the repressor protein activates the repressor protein) and when the repressor is in active state, it will repress the expression of the trp structural genes in the presence of Trp. BUT, when the repressor protein is mutated and the mutation prevents the binding of the trp, the repressor ALWAYS remains in its INACTIVE state irrespective of the presence or absence of Trp. Hence the operon will always be expressed at all conditions.

NOTE: If you need further explanation please feel free to comment on the answer with the specific doubt. I will be happy to help.

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