Reitveld et al. (2013) [which, by the way, had 203 authors!!!], found that the c
ID: 150104 • Letter: R
Question
Reitveld et al. (2013) [which, by the way, had 203 authors!!!], found that the combined effects of the three loci with highest LoD scores (of which rs9320913 is one) explained ~2% of the variance in educational attainment and cognitive function. If the LoD score is so strong, explain why these genes, although strongly associated with the traits of interest, have so little impact on phenotype
The figure below is from Reitveld et al.’s (2013) study entitled “GWAS of 126,559 Individuals Identifies Genetic Variants Associated with Educational Attainment”. What is the probability that alleles at locus rs9320913 are associated with educational attainment purely by chance (either as a raw decimal or a percent) [note: y-axis = LoD]?
rs9320913 rs9320913 100 10 0.8 06 80 04 0 2 T60 40 - 20 KLHL32 MIR21 13 --C6orf168 C6orf167 FBxL4 98.5 Position on chr6 (Mb) 97.5 98 99.5Explanation / Answer
in image recombination rate show distance between alleles at locus rs9320913 are associated with educational attainment in CM unit. Low Cm valve (blue dot) show high probabilty of association of alleles at locus rs9320913 are associated with educational attainment. there are blue dot freuency is 0.2.
so, 0.2= 1/5 = 20% probability