Part A: Describe the problem and identify why telomeres shorten in each replicat
ID: 150722 • Letter: P
Question
Part A: Describe the problem and identify why telomeres shorten in each replication cycle. Drag the terms on the left to the appropriate blanks on the right to complete the sentences. Terms can be used once, more than once, or not at all.
Part C: How does telomerase operate to synthesize telomeres? Drag the terms on the left to the appropriate blanks on the right to complete the sentences. Terms can be used once, more than once, or not at all.
There is a problem completing the replication of linear chromosomes at their ends. Part A Describe the problem and identify why telomeres shorten in each replication cycle Drag the terms on the left to the appropriate blanks on the right to complete the sentences. Terms can be used once, more than once, or not at all. Reset Help leading strand Linear chromosomal DNA is replicated by bidirectional replication, which involves leading and lagging strand synthesis. The problem replicating the ends of linear chromosomes is due to synthesis, which is responsible for replicating each at one DNA primer one DNA strand RNA primer lagging strand both DNA strands synthesis initiates at a and moves inward, away from chromosome end Because of this to the end. This happens every time a linear chromosome is replicated, which causes the ends of the chromosomes to shorten with each round of replication at end of the chromosome is not replicated all the way Part C How does telomerase operate to synthesize telomeres? Drag the terms on the left to the appropriate blanks on the right to complete the sentences. Terms can be used once, more than once, or not at all. Reset Help RNA 5' end 3' end end-shortening leading strand end-lengthening both DNA strands lagging strand DNA by telomerase counteracts DNA synthesis, due to resulting in the maintenance of chromosome length in cells expressing telomerase. Telomerase is a reverse transcriptase that syntheses DNA using an endogenous Telomerase syntheslzes DNA on to the a long single stranded DNA that is then replicated by as a template of of a chromosome, creating synthesis.Explanation / Answer
Linear chromosomal DNA is replicated by bidirectional replication, which involve leading and lagging strand synthesis. The problem replicating the ends of linear chromosome is due to lagging strand synthesis, which is responsible for replicating one DNA strand at one chromosomal end.
RNA primer synthesis initiates at a lagging strand and move inwards, away from the chromosomal end. Because of this, one DNA strand at one end of chromosome is not replicated all the way to the end. This happens every time a linear chromosome is replicated, which cause ends of the chromosome shorten with each round of replication.
End-lengthening by telomerase counteracts end-shortening due to both DNA strands. DNA synthesis, resulting in the maintenance of chromosomes length in the cells expressing telomerase. Telomerase is a reverse transcriptase that synthesize the DNA using an endogenous RNA as a template. Telomerase synthesize DNA on to the 5’ of lagging strand of a chromosome, creating a long single stranded DNA that is then replicated by 3’ synthesis.