I\'m struggling with the second portion of the question At each replication fork

Question

I'm struggling with the second portion of the question

At each replication fork, the synthesis of DNA proceeds at ~100 nucleotides per second in humans. Human chromosome 1 is about 250 million base pairs in length How long would it take to replicate chromosome 1 if it had a single origin of replication? Would the location of the ori on the chromosome have any effect on your answer? . In vivo, it takes about 8 hr to complete replication of human chromosome 1. What is theoretically the minimum number of oris on human chromosome 1? 5 3 parental DNA helix 5 newly synthesized strands 3" 5 5 3" 3 direction of replication- fork movement

Explanation / Answer

Answer:

Human chromosome 1 has 250 million base pairs in length. It takes 1 sec to copy around 100 nucleotides. To copy 250 million base pairs it will take 250,000,000/100 sec = 250,0000 sec = 694 hr

If the chromosome 1 has a single origin of replication it would take about 694 hr to replicate. But it takes 8 hr to replicate completely.

Hence the no of origin chromosome 1 has, is = 694/8 = ~87

Therefore theoretically minimum 87 numbers of origin of replication are present on human chromosome 1.

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