A recent study aimed to look at how excessive calorie intake can contribute to t
ID: 151737 • Letter: A
Question
A recent study aimed to look at how excessive calorie intake can contribute to the development of diabetes. Six healthy middle-aged men without a family history of diabetes were enrolled in the study, placed on bed rest, and then fed 6,000 kcal a day (~50% carbohydrates, ~35% fat, ~15% protein) for a week. (Boden et al., 2015)
1. a. The average metabolic rate measured for each participant was ~1,720 kcal/day. Based on this what do you predict happened to each participant’s body mass over the course of the 6 day study? Be sure to justify your answer.
b. After 2-3 days in the study, each participant began to show signs of insulin resistance. What does this mean and how can this be measured?
c. Over the course of the study it was determined that the increased oxidative stress that arose as a byproduct of excessive caloric intake, resulted in damage to the GLUT4 glucose transporters present in adipose and muscle tissue. What would you expect to happen as a result of this?
Explanation / Answer
a. If high and excess blood suger from diet is not absorbed sufficiently by cell even in the presence of insulin,the increase in level of blood sugar can result in classic hyperglycemic triad of polyphagia , polydipsia and polyuria. So here blood suger is more than daily requirement so it will lead to diabetes and weight gain may take place because hormone also taking more suger than required.
B. Insulin resistance is pathological condition in which body cell does not respond to insulin hormone normally.
In insulin resistance body does not take glucose for energy while use body fat so person body fat disapper gradually and suger concentration increase in blood and it's level remain high and all these sigh and indication are used to recognize insulin resistance.
C.when there is defect in GLUT4 transporter then glucose transport from blood to body cell stops .