Describe what the fate of the following skin graft swill be in the following exa
ID: 15483 • Letter: D
Question
Describe what the fate of the following skin graft swill be in the following examples of skin transplantation in the listed mice. In a sentence or less, explain why the outcome is the way it is. (12 points)
Balb/c (H-2d) skin graft on:
Balb/c
(B6 x C3H)F1
C3H (H-2k)
CBA/j (H-2k)
B10 (H-2b)
C3H-------------- (B6 x CBA/j F1) bone marrow chimera
(Balb/c x B6 F1) ------------- CBA/j bone marrow chimera
(C3H x B6 F1) ------------- (C3H x Balb/c F1) bone marrow chimera.
B6xBalb/c F1 (H-2bxd) skin graft on:
Balb/c
B6 x C3H F1
C3H (H-2k)
CBA/j (H-2k)
B10 (H-2b)
C3H------------ (B6 x CBA/j F1) bone marrow chimera
(Balb/c x B6) F1------------CBA/j bone marrow chimera
(C3H x B6 F1) ------------------(C3H x Balb/c F1) bone marrow chimera
CBA/j (H-2k) skin graft on:
Balb/c
B6 x C3H F1
C3H (H-2k)
CBA/j (H-2k)
B10 (H-2b)
C3H--------------- (B6 x CBA/j F1) bone marrow chimera
(Balb/c x B6) F1 --------------------- CBA/j bone marrow chimera
(C3H x B6 F1)-------------------- (C3H x Balb/c F1) bone marrow chimera.
Explanation / Answer
The A strain grafts were rejected while the CBA strain grafts were never rejected; the mice had becomespecifically tolerant to the CBA genotype,this tolerance was associated with a high degree of cellular chimaerism.
Since the bone marrow has been entirely replaced by the allogeneic cells, replenishment of the lymphoid system will be of these cells and not of the host type.