Pilin, Opa protein, and LOS (Lipooligosaccharide) help them attach to epithelial
ID: 161878 • Letter: P
Question
Pilin, Opa protein, and LOS (Lipooligosaccharide) help them attach to epithelial cells of the distal urethra or cervix and multiply. M Protein is a central player in pathogenesis. M protein is required for virulence and there are over 100 different M proteins (serotypes). A capsule that enhances the ability of the organisms to resist host defense mechanisms, such as complement-mediated killing in the bloodstream. This allows these organisms to grow to high numbers in the blood. This organism synthesizes a capsule containing both positive and negative charges. This capsule stimulates an immune response in the host that leads to intra-abdominal abscess formation. This toxin permanently activates adenylate cyclase which makes more cAMP and results in disruption of the activities of the mucosal ion pumps. This causes watery diarrhea and dehydration. Production of many virulence factors including coagulase, exfoliatin, superantigens, and other exotoxins. This organism is non-invasive, but its Shiga-like toxins can destroy mucosal cells. This organism has a great ability to resist destruction by stomach acid and invades the mucosal cells of the large intestine, but the invasion does not progress to become a systemic invasion. This organism causes a systemic infection with bacteremia. After the organism penetrates through the intestinal mucosa, it is taken up by macrophages and dendritic cells and delivered to the spleen and liver. The capsule is the main virulent factor of the organism. The bacteria causes disease not by exotoxins, but by causing an overwhelming inflammatory response. Streptococcus pyogenes Shigella dysenteriae, Neisseria meningitides E.coli O157:H7 Neisseria gonorrhoeae Salmonella typhi Vibrio cholerae Bacteroides fragilis Streptococcus pneumoniae Staphylococcus aureusExplanation / Answer
Neisseria gonorrhoeae E - 1
Streptococcus pyogenes A - 2
Neisseria meningitidis C - 3