Polycystic kidney disease is a rare autosomal recessive trait in humans. For thi

Question

Polycystic kidney disease is a rare autosomal recessive trait in humans. For this trait, assume that the allele ‘A’ is dominant and the allele ‘a’ is recessive. If there are 100 affected individuals (aa) in a population of 1 million, what is the expected frequency of homozygous (AA) individuals if the population is in Hardy-Weinberg equilibrium?

Polycystic kidney disease is a rare autosomal recessive trait in humans. For this trait, assume that the allele 'A' is dominant and the allele 'a' is recessive. If there are 100 affected individuals (aa) in a population of 1 million, what is the expected frequency of homozygous (AA) individuals if the population is in Hardy Weinberg equilibrium? 0.0196 0.98 0.0001 0.01

Explanation / Answer

Frequency of q2 = 100/1000000 = 0.0001, q = 0.01

Frequency of dominant allele (p) = 1-q = 1-0.01 = 0.99

Frequency of AA genotype = (0.99)2 = 0.98

Hence, the correct answer is option B.

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