Placlitaxel is a commonly used chemotherapeutic agent that acts as a cell poisor
ID: 168562 • Letter: P
Question
Placlitaxel is a commonly used chemotherapeutic agent that acts as a cell poisort by disrupting the mitotic spindle formation during cell division. This prevents proper distribution of chromosomes during cell division and triggers the cell to die. Based on what you know about cytoskeletal element function, which of the statements below a correct? Placlitaxel targets the microfilaments (actin microfilaments) and prevents them from performing their role of cleavage furrow formation during cell division. Placlitaxel targets microtubules since they are involved in mitotic spindle formation and are required for chromosome movements during cell division. Placlitaxel targets the intermediate filaments and prevents them from forming the nuclear lamina correctly. Placlitaxel is likely targeting the actin subunits themselves, therefore preventing the formation of microtubules and the mitotic spindle.Explanation / Answer
In the given following question option no 2 is correct because
Paclitaxel belongs to the family of cytoskeletal and target tubulin and prevent the dimer formation of tubulin, and stabilization of the microtubule polymer and stop the microtubules from disassembly. Apart from this paclitaxel arrest cell cycle at Go and G1 stage and G2/M stage and induce Apoptosis in cancer .The treatment by paclitaxel leads to irregularity of the mitotic spindle assembly, chromosome segregation, and as a result defects of cell division.