Scaduto et al. (2010 present the phylogenetic data from the samples of the HIV s
ID: 170664 • Letter: S
Question
Scaduto et al. (2010 present the phylogenetic data from the samples of the HIV strains that were collected from the six women, Padieu, and Genbank controls. The phylogeny based on one of the gene data sets is shown to the right (the color version is on the slide on display in class, and a couple of copies are on your table, too). Samples labeled "CC01" represent viruses that were collected from Padieu, while CC02-07 represent viruses collected from the women. The clade labeled "Outgroups" are the Genbank controls. A. Annotate the tree to identify the most recent shared ancestor for each clade of virus strains found in each woman. B. Make an evidence-based claim that indicates if the phylogenetic data support or refute the hypothesis. Be sure to differentiate between the evidence and the claim.Explanation / Answer
(a) 1. a compherensive study of the molecular epidemiologyof HCV genotyoe 4. PCR amplification of 60nHCV + isolates from the DRC. The genotype 4 common ancestor existed between 1650 and 1805.
2. This show that genotype 4 organised in central africa. multiple lineages were exported to north africa since~1850, including subtype 4a.
(b) 1.Several lines of evidence support a western african origin of genotype 2, with subsequent expansion eastwards.
2. the molecular clock results show that hcv is a more recent presence in benin ghana and central africa .