Codon number 156 157 158 159 160 161 162 163 Normal Person: ATG CAG GAA CTC AAT
ID: 176371 • Letter: C
Question
Codon number
156
157
158
159
160
161
162
163
Normal Person:
ATG
CAG
GAA
CTC
AAT
Codes for Asn
TCT
CGG
CTG
Your patient
ATG
CAG
GAA
CTC
TAT
Codes for Tyr
TCT
CGG
CTG
Keratins forms major components of skin, hair, horn and feathers and this protein is robust and relatively insoluble and their quaternary structure play important roles in the maintenance of physical structure of animals. In addition to this the secondary structures (the -helix and -sheet) plays important role in the architecture of keratins. If Asn at 160th position is replace with tyrosine then the tyrosine being a hydrophilic residue will try to destabilize the transmembrane state and as tyrosine with hydrophilic domains cannot cross the membrane and thus results in the blocking of any transmembrane and non-transmembrane equilibration state and the consequence change brought by these charged ionized residues will destabilize the transmembrane state of keratin structure.
K10 , suprabasal (EH:160 (Tyr-----> Asp) This substitution will bring a change in the suprabasal specific keratin polypeptide expression thus filament stability will be disturbed. This altered expression along with structural composition change has resulted in the thickening of the skin on his palms and soles.
Please explain when the Asn is in the keratin structure and how changing it to Tyr affects the protein?
156
157
158
159
160
161
162
163
Normal Person:
ATG
CAG
GAA
CTC
AAT
Codes for Asn
TCT
CGG
CTG
Your patient
ATG
CAG
GAA
CTC
TAT
Codes for Tyr
TCT
CGG
CTG
Explanation / Answer
Keratin forms a major component of skin, hair, horn and feathers and this protein is robust and relatively insoluble and their quaternary structure play important roles in the maintenance of physical structure of animals. In addition to this the secondary structures (the -helix and -sheet) plays important role in the architecture of keratins.
If Asn at 160th position is replace with tyrosine then the tyrosine being a hydrophilic residue will try to destabilize the transmembrane state and as tyrosine with hydrophilic domains cannot cross the membrane and thus results in the blocking of any transmembrane and non-transmembrane equilibration state and the consequence change brought by these charged ionized residues will destabilize the transmembrane state of keratin structure.
K10 , suprabasal (EH:160 (Tyr-----> Asp) This substitution will bring a change in the suprabasal specific keratin polypeptide expression thus filament stability will be disturbed. This altered expression along with structural composition change has resulted in the thickening of the skin on his palms and soles.