Parkinson’s disease may be treated by (select all answers that apply): A. Supply
ID: 177104 • Letter: P
Question
Parkinson’s disease may be treated by (select all answers that apply):
A. Supplying L-Dopa, a precursor of dopamine, normally produced by substantia nigra pars compacta.
B. Electrical stimulation of the locus coeruleus.
C. Electrical stimulation of the subthalamic nucleus.
D. Electrical stimulation of the substantia nigra pars compacta.
A. Supplying L-Dopa, a precursor of dopamine, normally produced by substantia nigra pars compacta.
B. Electrical stimulation of the locus coeruleus.
C. Electrical stimulation of the subthalamic nucleus.
D. Electrical stimulation of the substantia nigra pars compacta.
Explanation / Answer
A). A. Supplying L-Dopa, a precursor of dopamine, normally produced by substantia nigra pars compacta.
B. Electrical stimulation of the locus coeruleus.
C). Electrical stimulation of the subthalamic nucleus.
Parkinson’s disease (PD) is a neurodegenerative disorder characterized by the muscular rigidity, difficulty with movement (bradykinesia or akinesia), tremors and change in body posture.
The pathophysiology of disease underlies the destruction of dopaminergic neurons in the substantia nigra and excess release of acetylcholine, which impairs the muscular movement and causes rigidity of muscles and tremor. Electrical stimulation of substantia nigra did not improve movement in Parkinson's disease.