Please help with this bio chem! 1. From primary sequence to secondary structure
ID: 192604 • Letter: P
Question
Please help with this bio chem!
1. From primary sequence to secondary structure (18 points). Answer the following questions based on these three primary sequences: I. FQIDMELKV I AQYGPNLPA II FNSVLQDIE a) which sequence is most likely to form a -strand, with one surface facing the protein interior and the other exposed to water? Justify your answer with one sentence. b) Which sequence is most likely to form an amphiphilic a-helix? Justify your answer with one sentence and a helical wheel diagram. c) which sequence is unlikely to form either -sheet or a-helical structure? Justify your answer with one sentence.Explanation / Answer
Valine (V) and Isoleucine (I) favour Beta sheets
Alanine (A), Leucine (L) and Glutamate (E) favour -Helix
'I' can form -Sheets, because it contain V and I amino acids
'II' can form -Helix. Because it contain A, L amino acids
'III' can't form any secondary structure. Because it compromise alternative & form Amino acids