In humans the hairless locus codes for a follicular protein found associated wit
ID: 19552 • Letter: I
Question
In humans the hairless locus codes for a follicular protein found associated with normal hair development. The normal allele at this locus is denoted with B. A recessive allele b is associated with reduced hair density and increased hair loss in Bb and bb men. A recent study showed of 1778 men showed that 1194 were BB, 526 were Bb, and 58 were bb.A. What are the genotype frequencies?
B. What are the allele frequencies?
C. Are these two alleles in Hardy-Weinberg equilibrium? How do you know?
D. What information do you need to determine whether the alleles will be in equilibrium in the next generation?
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Explanation / Answer
Observed
Expected
genotype frequencies
BB,
P^2
1194
0.82 x0.82=
0.67
Bb
2pq
526
2x0.82x 0.18
0.3
bb
q^2
58
0.18 x0.18
0.03
1
P^2+2pq+ q^2=1
By square root method
Frequency of recessive allele-----
q^2=58/1778 q=0.18
P+q=1
P=1-0.18=0.82
Observed
Expected
genotype frequencies
BB,
P^2
1194
0.82 x0.82=
0.67
Bb
2pq
526
2x0.82x 0.18
0.3
bb
q^2
58
0.18 x0.18
0.03
1