Glucose-6-phosphate dehydrogenase is also found in yeast, The KM for glucose-6-p

ID: 197682 • Letter: G

Question

Glucose-6-phosphate dehydrogenase is also found in yeast,

The KM for glucose-6-phosphate in yeast is 2x10^-5 The KM for NADP1

is 2 1 x10^-6 Yeast glucose-6-phosphate dehydrogenase can be

inhibited by a number of cellular agents whose KI values are listed

in the following table.

Inhibitor KI (M)

Inorganic phosphate:1 x10^-1M

Glucosamine-6-phosphate 7x10^-4M

NADPH 2.7 x10^-5M

(a) Which is the most effective inhibitor? Explain.

(b) Which inhibitor(s) is (are) likely to be completely ineffective

under normal cellular conditions? Explain.

C) NADPH H+ HO OH glucose-6-1 HO phosphate dehydrogenase H OH H OH Glucose-6-phosphate 6-Phosphoglucono-8-lactone

Answer:

Based on the given information:

Yeast glucose-6-phosphate dehydrogenase Inhibitor Ki (M)

(a) Which is the most effective inhibitor? Explain.

(b) Which inhibitor(s) is (are) likely to be completely ineffective under normal cellular conditions? Explain.