Please follow the links below and be as specefic answering the question. the two
ID: 198891 • Letter: P
Question
Please follow the links below and be as specefic answering the question.
the two case studies on Naeglaria fowleri and the paper on Balamuthia mandrillaris. What are the similarities and differences in the life cycles, transmission and pathogenesis of both parasites? What methods are used to diagnose both parasites and why is necessary to culture both parasites? Why are both parasites call opportunistic?
https://pdfs.semanticscholar.org/8209/3c9a2847a29764ed5d988b06dfbee57fb8fb.pdf
https://academic.oup.com/labmed/article/47/2/149/2937887
https://academic.oup.com/cid/article/54/6/805/290592
Explanation / Answer
Similarity in life cycle: Balamuthia mandrillaris and Naegleria fowleri have cyst and trophozite in their life cycle.
Differences in life cycle: Balamuthia mandrillaris have two stages in life cycle that is cysts and trophozoites whereas Naegleria fowleri have three stages in life cycle cyst , trophozoite , and flagellate.
Transmission of pathogen: Balamuthia mandrillaris is transmitted through organ transplantation whereas Naegleria fowleri enter the human when the person do swimming , they enter through nose and damage the brain.
Pathogenesis
Naegleria fowleri infect the human in trophozite stage and damage the brain. Balamuthia mandrillaris infect the pathogen through virulence factors.
Diagnosis is by immunofluorescence and polymerase chain reaction. To help in the diagnosis, the pathogen should be cultured , so that there is ample sample for diagnosis.
Both the pathogen are called as opportunistic because, normally they do not cause infection, but when the immune system of the host is weaken, then they infect the pathogen.