Pick the correcty answer If a mutation that inactivated telomerase occurred in a
ID: 200809 • Letter: P
Question
Pick the correcty answer
If a mutation that inactivated telomerase occurred in a cell (telomerase activity in the cell = zero), what do you expect the outcome to be?
Somatic or body cells have very little telomerase. As a result, the telomeres within these (proliferating) cells _____ with each cell division.
A researcher is studying telomerase in four types of mouse cells: brain cells, skin cells, blood cells, and gametes (sperm/eggs). What do you suspect she will find?
In the PCR process, if we assume that each cycle takes five minutes, how many-fold amplifications would be accomplished in one hour?
One feature that virtually all plasmid vectors have in common is the polylinker (also called a multiple cloning site). This is important because
Pick the correcty answer
If a mutation that inactivated telomerase occurred in a cell (telomerase activity in the cell = zero), what do you expect the outcome to be?
The position of the centromere would shift at each replication cycle, eventually leading to mutations in the genetic information and cell death. The number of tandem repeats would increase with each replication cycle, eventually leading to a large unstable chromosome and cell death. The telomeres would shorten at each replication cycle, eventually leading to loss of essential genetic information and cell death. DNA primase would be unable to bind to the 5 end of the template strand, eventually causing a reduction in chromosome size and cell death.Explanation / Answer
If a mutation that inactivated telomerase occurred in a cell (telomerase activity in the cell = zero), what do you expect the outcome to be?
The answer is - The telomeres would shorten at each replication cycle, eventually leading to loss of essential genetic information and cell death.
All eukaryotic chromosomes end in telomeres. The terminal that is extreme 5 prime end of each strand fails to replicate. This occurs because DNA polymerase fails to bind to this terminal ends, actually it slips. So a special enyme called telomerase is employed to catalyze the replication at telomere.
So if there is no telomerase activity then in each cycle of replication few terminal sequences would be lost eventually genetic information would be lost.
Somatic or body cells have very little telomerase. As a result, the telomeres within these (proliferating) cells _____ with each cell division.
The answer is - shorten.
A researcher is studying telomerase in four types of mouse cells: brain cells, skin cells, blood cells, and gametes (sperm/eggs). What do you suspect she will find?
The answer is - telomerase activity/amount will be highest in gametes (sperm/eggs).
In normal somatic cells telomerase activity is not observed. So they can replicate a definite number of time after that they will under go apoptosis. But germ cells that is sperm or egg shows telomerase activity.