Collagen is constitutively secreted by fibroblast cells, a type of connective ti
ID: 204375 • Letter: C
Question
Collagen is constitutively secreted by fibroblast cells, a type of connective tissue cell. If you had a patient in which collagen is synthesized normally, but fails to be secreted into the extracellular matrix, which of the following would you examine as the likely cause of this problem? A. A kinesin disorder B. A Ca++ deficiency C. A failure of the Na+/K+ ATPase D. A H+ pump disorder Collagen is constitutively secreted by fibroblast cells, a type of connective tissue cell. If you had a patient in which collagen is synthesized normally, but fails to be secreted into the extracellular matrix, which of the following would you examine as the likely cause of this problem? A. A kinesin disorder B. A Ca++ deficiency C. A failure of the Na+/K+ ATPase D. A H+ pump disorder A. A kinesin disorder B. A Ca++ deficiency C. A failure of the Na+/K+ ATPase D. A H+ pump disorderExplanation / Answer
Option B is the correct answer. Collagen secretion into the extracellular matrix is COPII vesicles mediated which involves the packaging of collagen and transport it into the extracellular matrix. A Ca++ deficiency results in the decreased level of COPII coats and thus decreased secretion of collagen into extracellular matrix.