Metals in Medicine (5 pts) Manganese has been a favorite metal for making contra
ID: 207668 • Letter: M
Question
Metals in Medicine (5 pts) Manganese has been a favorite metal for making contrasting disgnostic agents to be used in MRI imaging, until the more expensive gadolinium took over What is the to manganese for such purpose? most desired feature in a contrast agent, and why would gadolinium be superior B (10 pts) Cis-platin t(Pt(Cl)(NH)] is used for cancer treatment. Its clinical activity is accepted to follow from its ability to interact with the DNA of cancer cells. Use the following DNA strand to illustrate how cis-platin interacts with DNA. Write a statement to clarify your answer. (G stands for guanine!) 2C (5 pts) Give an example of a vanadium complex that can be used to an insulin minic in the therapeutic treatment of diabetes.Explanation / Answer
2A= contrast agent enhances and improves the quality of the MRI images (or pictures). This allows the radiologist to more accurately report on how your body is working and whether there is any disease or abnormality present.
Paramagnetic and superparamagnetic metals are used as contrast materials for magnetic resonance (MR) based techniques.
Gadolinium contrast media consist of complex molecules, arrangements of atoms held together by chemical bonds. The chemical bonds are made between a gadolinium ion and a carrier molecule . A chelating agent prevents the toxicity of gadolinium while maintaining its contrast properties.Gadolinium contrast medium is used in about 1 in 3 of MRI scans to improve the clarity of the images or pictures of your body’s internal structures. This improves the diagnostic accuracy of the MRI scan. For example, it improves the visibility of inflammation, tumours, blood vessels and, for some organs, blood supply.
2B=cisplatin is a well-known chemotherapeutic drug. It has been used for treatment of numerous human cancers including bladder, head and neck, lung, ovarian, and testicular cancers. It is effective against various types of cancers, including carcinomas, germ cell tumors, lymphomas, and sarcomas. Its mode of action has been linked to its ability to crosslink with the purine bases on the DNA; interfering with DNA repair mechanisms, causing DNA damage, and subsequently inducing apoptosis in cancer cells
2C=paramagnetic vanadyl (+4 oxidation state of vanadium) complexes with different coordination modes.
Bis(maltolato)vanadium(III)-Polypyridyl Complexes