I. Consult your texibook fior the genetic code. Examine the following nacleotide
ID: 212419 • Letter: I
Question
I. Consult your texibook fior the genetic code. Examine the following nacleotide sequence from the senas strand of DNA. What is the amino acid sequence of the encoded protein ATG-CCT-TAC-GCC-CCT-GGA-GAC-GAA-AAG-AAG-Goz 2. A type of gene therapy called RNA Interference (RNA) is being investigated to treat Huntington'i disease. This disease is the result of a mutation in the DNA that results in the synuhesia of a nervous system protein with an altered amino acid sequence. The mutated protein forms clumps, which causes nervous system defects. To treat this disease, scientists synthesize short sequences of RNA (siRNA, or small interfering RNA) that forms base pairs with the mRNA that codes for the mutated protcin. . Design an siRNA that will interfere with the synthesis of the protcin shown in Model 2 b. Explain how the addition of the siRNA will prevent the synthesis of the mutated protein. c. What are the difficulties that must be overcome in order for RNA interference to be an effective technique for treating the disease!Explanation / Answer
1. The answer is
ATG CCT TAC GCC CCT GGA GAC GAA AAG AAG GGT - quirey seq
The opposite strand of Template strad is called as sence strand. The template strand is called as antisense strand.
The sequence of sense strand is almost similar with mRNA except in thymine in DNA, it is replaced with Uracil in RNA.
So, the answers are
TACGGAATGCGGGGACCTCTGCTTTTCTTCCCA - Template DNA
ATGCCTTACGCCCCTGGAGACGAAAAGAAGGGT - Sense strand
AUGCCUUACGCCCCUGGAGACGAAAAGAAGGGU - mRNA
1 AUG CCU UAC GCC CCU GGA GAC GAA AAG AAG GGU 33 - Codons on mRNA
1 Met Pro Tyr Ala Pro Gly Asp Glu Lys Lys Gly 11 - Polypeptide or protein
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