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Use the following information for the next 5 questions (until you see a solid li

ID: 213506 • Letter: U

Question

Use the following information for the next 5 questions (until you see a solid line): Functional imaging studies indicate that a neuronal pathway involving the neurotransmitter dopamine may be involved in the development of aicoholism. In response to this research, Jane Schmoe hypothesized that an alleleD) ofa gene that influences dopamine production contributes to alcoholism. She genotyped a random sample of 10,000 newborn babies. She also estimated the lifetime fecundity of the three genotypes based on the sample of newborns -note that this fecundity measure includes both survival to reproductive age and reproduction once mature. Her data is listed below Newborns Average lifetime Newborns 2500 5000 2500 D.D. 62) The relative fitness of the "D allele is: A) 0.1 B) 0.3 C) 0.5 D) 0.7 E) 0.9 63) The relative fitness of the "D allele is: A) 0.1 B) 0.3 C) 0.5 D) 0.7 E) 0.9 64) The mean relative fitness of the population is: A) 0.1 B) 0.2 C) 0.5 D) 0.7 E) 0.9 65) The expected proportion of the D, allele in the following generation is: A) 03 A) 0.1 B) 0.3 C) 0.5 D) 0.7 E) 0.9 66) The expected change in the proportion of D, allele is: A) +0.1 B) +02 C) 02 D) +0.7 E) -09

Explanation / Answer

Allele frequencies are more useful than genotype frequency because alleles rarely undergo mutation in a single generation, so are stable in their transmission from one generation to the next. In contrast, genotypes are not permanent. They are broken up by the processes of segregation and recombination that take place during meiosis.

Furthermore, we can deduce the expected genotype frequencies in the next generation from knowledge of only the allele frequencies in the previous generation.

Zygotic genotype frequencies are predictable from gamete frequencies, assuming random mating, and allele frequencies do not change from generation to generation under this scenario.

Genotype frequencies are given by the following rules:

Also, p2+2pq+q2=1.

62. a

63. c

64. c

65. b

66. e