Colo small bowel cancer (SBC) and colon polyps. ** Slides from class provide hel
ID: 215440 • Letter: C
Question
Colo small bowel cancer (SBC) and colon polyps. ** Slides from class provide helpful information for this case. n Cancer Case: Sally is 25 years old and she has been referred for a genetic evaluation due to a family colon cancer (CRC) and other cancers (UT-uterine cancer). Her father is 50 and has a history of 11/11/2004 Diagnosis Polyps Diagnosis CRC Diagnosis Ocher Ca Note: This symbol does NOT indicate a carrier individual. Other Ca UT Ca Other Ca CRC 49 Other Ca 53 CRC 51 CRC 53 CRC S3 CRC 40 CRC 51 Polyps 50 CRC 53 CRC S0 CRC Hysterectomy Other Ca 480ther Ca Gastric ca Pancreatic ca Polyps 48 Crohn's Crohn's Based on the pedigree, would you classify her risk for inherited cancer syndrome as low, moderate or high? List 3 aspects of the family and medical history that support your conclusion What is the most probable inherited colon cancer syndrome diagnosis for this fanily?Explanation / Answer
She is a high risk patient with about 75% chance of getting cancer.
Based on the pedigree chart, we can say that the concer is present on a dominant allele. This is based on observation that in 2nd generation both are affected and in 3rd generation 2/3 are affected and in the 4th this increase to 75%.
Asso Grandparents of Crrier has CRC 51 and 53 and her father has SBCa and polyps. IF these are spread in through dominant allels, that chances that she recieved one is significantly higher.
B) CRC is 53 is the most probable colon cancer inherited in the family. As it is present in most of the members of the family.