Breast Cance to the genetics clinic based on his family history of multiple canc
ID: 216150 • Letter: B
Question
Breast Cance to the genetics clinic based on his family history of multiple cancers. r Case 1: Mr. Franklin is a 35 year old with no personal history of cancer that has been referred African American African American Symbol defintions Cancer diagnosis d. 53 d. 83 d. 72 906 Prostate cancer, Breast cancer Colon cancer Liver cancer 52 (alcoholic) 81 75 72 61 d 39 Lung cancer, 52 Breast cancer 35 (smoker) 35 Based on the pedigree, would you classify his risk for an inherited cancer syndrome as low, moderate or high? List 3 aspects of the family and medical history that support your conclusion. Would you recommend genetic testing for this patient? Why or why not?Explanation / Answer
35 yr old Franklin was at high risk of inherited cancer syndrome
Family cancer syndrome in which genetic mutations in 1 or more genes predispose the affected individuals to development of cancer
They already have 1 copy of gene mutated when both copies involve they develop cancer
As Franklin having
1. Positive family tree of cancers
Multiple family members suffered with cancer
2.Father having lung cancer due to smoking so he also may be exposed to PASSIVE smoking in which he may not smoke but he is exposed to smoke
3.Age is directly proportional to incidence
So these all factors made Franklin to be classified under high risk
2.Yes I recommend genetic testing
In thiese one can find the mutated genes or chromosomes it may be done by body fluids like blood saliva and Buccal swab. Are most common
Many types of genetic tests available like full gene sequencing and 1 mutation analysis