Ch 12 Hw Chapter 12 Question 14-case study previous l 18 of 18 l return to assig
ID: 226923 • Letter: C
Question
Ch 12 Hw Chapter 12 Question 14-case study previous l 18 of 18 l return to assign Chapter 12 Question 14 Case Study What are the molecular targets of anticancer drugs? The bark of the Pacific yew tree (Tax brevilolia) was the original source of one of the most effective drugs for treating tumors of the breast, lung, and other sites. Taxol, a chemical extracted from this bark, kills actively replicating cells by inhibiting the depolymerization of microtubules. Why are microtubules good targets for killing cancerous cells? Part A Aggressive forms of breast cancer are resistant to Taxol chemotherapy. In these cancers, the gene encoding a protein called stathmin is overexpressed. To investigate the mechanism of action of stathmin, investigators measured tumor volume over time in mice with aggressive cancers under three conditions: no treatment (contro), Taxol treatment, and treatment with expression turned off (Taxol +Astathmin). Their results are shown below. Use to how the stathmin affects microtubule stability. Control 1.2 1.0 0.8 Taxol 0.6 04 Taxol stathmin 10 20 30 40 50 Days Source: C. Miceli et al. 2013. Cancer Gone Thorapy 20 298 307. The stathmin protein makes the cell membrane less permeable for the compounds like Taxol, therefore, Taxol O couldn't reach a satisfactory concentration within the cell and doesn't affect significantly on microtubules' depolymerizationExplanation / Answer
answer:
stathmin protein decease the stability of microtubules. When stathmin is absent , the microtubule-stabilisng effect of taxol is enhanced and the cells more likely to arrest
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Stathmin, otherwise called metablastin and oncoprotein 18 is a protein that in people is encoded by the STMN1 quality.
Stathmin is a very rationed 17 kDa protein that is vital for the direction of the cell cytoskeleton. Changes in the cytoskeleton are essential in light of the fact that the cytoskeleton is a framework required for some phone procedures, for example, cytoplasmic association, cell division and cell motility. More particularly, stathmin is critical in managing the cell cycle. It is discovered exclusively in eukaryotes.
Its capacity as a critical administrative protein of microtubule elements has been well-characterized. Eukaryotic microtubules are one of three noteworthy parts of the cell's cytoskeleton. They are very dynamic structures that ceaselessly interchange amongst gathering and dismantling. Stathmin plays out a critical capacity in managing quick microtubule redesigning of the cytoskeleton because of the cell's needs. Microtubules are round and hollow polymers of ,-tubulin. Their gathering is to a limited extent controlled by the convergence of free tubulin in the cytoplasm.
At low centralizations of free tubulin, the development rate at the microtubule finishes is hindered and results in an expanded rate of depolymerization .