Although ligand binding to 7TM receptors initiates a signal transduction pathway
ID: 25144 • Letter: A
Question
Although ligand binding to 7TM receptors initiates a signal transduction pathway by triggering a change in tertiary structure, another class of receptors involves dimerization upon ligand binding. The result of this is that:A. intracellular protein kinase domains are brought together and activate one another by cross-phosphorylation.
B. intracellular domains acting as second messengers are proteolytically cleaved and free to move through the cytoplasm.
C. the intracellular domains are changed from a conformation having little organized structure into a highly organized structure.
Explanation / Answer
A. intracellular protein kinase domains are brought together and activate one another by cross-phosphorylation.