Cohesins are the proteins that hold sister chromatids together at the beginning

Question

Cohesins are the proteins that hold sister chromatids together at the beginning of mitosis. Which of the following best describes how they are regulated to allow chromosome separation at anaphase The spindle checkpoint triggers a caspase proteolytic cascade which targets cohesins for degradation. The spindle apparatus generates physical tension that is too strong for the cohesin proteins to withstand. The anaphase promoting complex causes the degradation of an inhibitor, releasing a protease that cleaves the cohesins. O O M-cdk phosphorylates them which causes them to dissociate.

Explanation / Answer

The protein which cleaves cohesin is called as Separase. This separase is kept in an inactive state with the help of another protein securin. Anaphase-promoting complex helps in the cleavage of securin(Inhibitor) and thus help's in the activation of separase(Proteases) protein. Once activated separase cleave cohesin and thus helps in releases of chromatids.

So correct answer is option - C

Related Questions

Navigate

• Browse (All)
• Browse C
• Subjects

---