Please help with some epgenetics! I got partial credite for the answers I put bu
ID: 253399 • Letter: P
Question
Please help with some epgenetics! I got partial credite for the answers I put but I'm not sure which ones I got wrong!
1) Match the repair pathway to the type of damage it most commonly repairs.
a. Non-homologous end joining
b. Nucleotide excision repair
c. Mismatch repair
d. homologous recombination
e. photolyse
Choices: double strand breaks, UV-induced photodamage, replication error, spontaneous depurination, 5-methyl cytosine
My answer: a. 5-methyl cytosine, b. UV-induced photodamage, c. replication error, d. double strand breaks, e. spontaneous depurination
2) Match the human diseas to the repair patheay that is deficient that disease. Answers may be used more than once.
a. Hereditary polypsis colorectal cancer
b. Xeroderma pigmentosum
c. Ataxia telangiectasia
d. Fanconi Anemia
Choices: mismatch repair, nucleotide excision repair, double strand break repair, base excision repair, photolyse
My answer: a. mismatch repair, b. nucleotide excision repair, c. mismatch repair, d. double strand break repair
3) ____ (a) is a histone chaperone that is recruited by the PCNA and binds to newly synthesized _____(b).
______ (c) is a histone chaperone that acts during the replication-independent assembly pathway, when _____ (d) is incorporated into chromatin.
______(e) is a thrid chaperone that is recruited to replication forks by the replicative helicase.
My answers: a. CAF1, b. H3 and H4, c. H3.3, d. nucleosomes, e. ASF
Explanation / Answer
a. Non-homologous end joining: double strand breaks
b. Nucleotide excision repair: UV-induced photodamage
c. Mismatch repair: replication error, spontaneous depurination
d. homologous recombination: double strand breaks
e. photolyse: UV-induced photodamage
a. Hereditary polypsis colorectal cancer: mismatch repair
b. Xeroderma pigmentosum: nucleotide excision repair
c. Ataxia telangiectasia: base excision repair
d. Fanconi Anemia: nucleotide excision repair
CAF1 is a histone chaperone that is recruited by the PCNA and binds to newly synthesized H3 and H4.
H1 is a histone chaperone that acts during the replication-independent assembly pathway, when H3.3 is incorporated into chromatin.
ASF is a thrid chaperone that is recruited to replication forks by the replicative helicase.