Please help, I do not understand. I am assuming it’s turning off, but not sure.

Question

Please help, I do not understand. I am assuming it’s turning off, but not sure. 6:11 PM Nicole @ Fresno State-Couldn't Sync Home Insert Draw View Class Notebook ?Lasso Select + ?ink to Shape Drawing Mode 14. Acetylation and phosphorylation positi change the overall charge. A modification of H3 at K23 (H3K23) leads to: lation remove the positive charge on the histones, and methylation does not A) Turning on the relevant gene B) Turning off the relevant gene H4 15. Figure right shows different sequence components making up the human genome. What is the

Explanation / Answer

It turns off the gene.

As you could see in H2A and H2B, the histones are acetylated and phosphorylated at various position which removes positive charge of the histone protein which in turn causes histone to bound to DNA less tightly. This leads to the Turning On of the relevant gene.

Whereas in the H3 protein many regions are already methylated namely K4, K9, K27.

So when the K23 region (which is already acetylated) is methylated/modified, this will alter the charge of the histone. This makes the Histone to bind to the DNA very tightly and causes the relevant gene to turn off .

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