Mice with a knockout for the UCP-2 gene in the pancreas were analyzed for their
ID: 261462 • Letter: M
Question
Mice with a knockout for the UCP-2 gene in the pancreas were analyzed for their response to a glucose tolerance test (GTT), insulin tolerance test (ITT) and ability to synthesize insulin (C-peptide). Below are the results from those experiments (total 20 pts).
Explain why deletion of UCP-2 in the pancreas improves glucose homeostasis (5pts).
Draw the pathway in the pancreas for glucose stimulated insulin secretion. (5pts)
List one incretin and explain the actions of it (5pts)
What is incretin related therapy and how does it improve insulin resistance in type 2 diabetic patients (5pts).
Explanation / Answer
Higher cAMP à more Ca+2 and PKA à insulin