QUESTION 4 Human fibroblasts (skin cells) do not normally express telomerase. Af

Question

QUESTION 4 Human fibroblasts (skin cells) do not normally express telomerase. After 60 cell divisions they become senescent. Fibroblasts in which telomerase has been turned on become immortal. Assuming an average telomere length of -6000 bp at birth and a minumum functional telomere length of -360 estimate the following parameters AGGGTT repeats at birth Nucleotides lost per cell division AGGGTT repeats at senescence Nucleotides needed to be replaced per cell division to achieve immortalit) 10,000 6,000 1,000 600 100 60 10 6

Explanation / Answer

AGGGTT at birth = 6000

nucleotide lost per division = 100 (100*60=6000)

AGGGTT at senescence = 100

nucleotide needed to be replace per division to acheive immortality = 60

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