Please explain everything in great detail. Thank you in advance 11. (13 points)

Question

Please explain everything in great detail. Thank you in advance

11. (13 points) Annabeth and Percy are concerned about having a child with Canavan disease, which causes brain tissue degeneration. This condition, which is very rare, has affected Annebeth's uncle (her mother's brother) and Percy's sister. No one else in either family has the condition. Show your work and circle your answer. a) (1 point) What is the most likely mode of inheritance of Canavan disease? Be specific Autosomal recessive b) (4 points) Based on their family history, what is the probability Annabeth and Percy's first child will be affected by Canavan disease? P(child with Canavan disease) -P(Annabeth is a carrier) x P(Percy is a carrier) x H- (2/3 x ) x (2/3) x 1/18-0.0556-5.56% c) (4 points) What is the probability their first child will be a carrier? P(child with Aa) -(1/3*2/34% 2/3*2/3*1/2+ 1/3* 1/3*1/2) 7/18 -0.389-38.9% The couple is also concerned about their child inheriting hemophilia, another rare disease, which is X-linked. Annabeth's brother and Tyson (Percy's brother) have the condition. No one else in either family has the condition. d) (4 points) What is the probability their first child will be affected by both diseases? P(child with Canavan disease) x P(child with hemophilia) 1/18 x P(Annabeth is XHXh) x P(Xh from Annabeth) x P(Y from Percy) = 1 /18 x ½ x ½ x ½ 1/144 0.0069 = 0.69%

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Please explain everything in great detail. Thank you in advance 11. (13 points)

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