Predict where each mutant protein will go (as in, final destination), based on t
ID: 264224 • Letter: P
Question
Predict where each mutant protein will go (as in, final destination), based on the set of sorting sequences it has.
Hint: think about what set of sorting sequences the normal, unmutated protein would have, then think about what sorting sequences the protein would have after the changes are made. Then, figure out where a protein with these new sorting sequences would end up.
a cytoskeletal protein, with MTS added to it
Cyt-P450 enzyme, with the ER-RS removed
Hint: we learned about the function of P450 in the slides.
Oligosaccharyl transferase, with the ER-SS and ER-RS removed
Hint: oligosaccharyl transferase adds the initial oligosaccharide (initial glycosylation)
DNA polymerase, with the NLS swapped out and replaced with ER-RS
glucocerebrosidase, with no M6P tag
ER
cytoplasm
golgi
secreted
stuck forever inside a vesicle
nucleus
mitochondria
- A. B. C. D. E. F. G.a cytoskeletal protein, with MTS added to it
- A. B. C. D. E. F. G.Cyt-P450 enzyme, with the ER-RS removed
Hint: we learned about the function of P450 in the slides.
- A. B. C. D. E. F. G.Oligosaccharyl transferase, with the ER-SS and ER-RS removed
Hint: oligosaccharyl transferase adds the initial oligosaccharide (initial glycosylation)
- A. B. C. D. E. F. G.DNA polymerase, with the NLS swapped out and replaced with ER-RS
- A. B. C. D. E. F. G.glucocerebrosidase, with no M6P tag
A.ER
B.cytoplasm
C.golgi
D.secreted
E.stuck forever inside a vesicle
F.nucleus
G.mitochondria
Explanation / Answer
Predict where each mutant protein will go (as in, final destination), based on t