Select the event that is essential for the transcription of the immunoglobulin l

Question

Select the event that is essential for the transcription of the immunoglobulin light-chain gene. In the choices below, V is the variable region, C is the constant region, and J is the joining region of the light-chain gene. O RNA splicing removes introns from the V and J region O Somatic mutations in the V region alter the DNA sequence. O O Rearrangement of the V-region DNA brings the promoter closer to the enhancer. The leader sequence is cleaved off from the V region. Imprecise recombination at the site of VJ fusion produces hypervariable regions.

Explanation / Answer

Rearrangement of the V- region DNA brings the promoter closer to the enhancer.

The promoter is brought closer to the enhancer by somatic rearrangements. The V(D)J recombinations occur in developing lymphocytes.

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