Points 2. The viral protein Integrase is responsible for integrating the double-

Question

Points 2. The viral protein Integrase is responsible for integrating the double-stranded viral genome into the host chromosome, causing it to become a provirus. The inhibitors that are directed toward the viral integrase are in their third generation and yet they are still used very readily as resistance to the drugs by Integrase happens very rapidly. You have discovered a new Integrase inhibitor that you name Inhibtivir. Explain the mechanism by which the viral Integrase becomes resistant to Inhibtivir. (10 Points) not

Explanation / Answer

The virus is just a nucleic acid which replicates itself within a specific host or couple of hosts. To bypass immune system challenges and other drugs effects, they changes themselves very rapidly. Often we can see mutation rate in virus is very high and rapid. High mutation rates causes the changes of amaino acid structures of viral proteins which disable the drug targets. If drug target regions got changed then the viral proteins become resistant to that particular type of drug.

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